Article
Evidence that an HMGA1 gene variant associates with type 2 diabetes, body mass index, and high-density lipoprotein cholesterol in a Hispanic-American population.
Metabolic syndrome and related disorders - 1 Feb 2014
Pullinger Clive R, Goldfine Ira D, Tanyolaç Sinan, Movsesyan Irina, Faynboym Mark, Durlach Vincent, Chiefari Eusebio, Foti Daniela P, Frost Philip H, Malloy Mary J, Brunetti Antonio, Kane John P
Abstract excerpt
BACKGROUND: High-mobility group AT-hook 1 (HMGA1) is an important regulator of the insulin receptor gene. We have previously shown in three populations of white European ancestry that the HMGA1 gene variant rs146052672 (also designated IVS5-13insC) is associated with type 2 diabetes mellitus (T2DM). The aim of this study was to measure the frequency of this variant and to determine the degree of the association...
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