Article
Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism.
Cell death and differentiation - 1 Jan 2017
Rodríguez Cristina, Sobrino Tomás, Agulla Jesús, Bobo-Jiménez Verónica, Ramos-Araque María E, Duarte Juan J, Gómez-Sánchez José C, Bolaños Juan P, Castillo José, Almeida Ángeles
Abstract excerpt
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke that lacks effective therapy and reliable prognosis. Neovascularization following ICH is an essential compensatory response that mediates brain repair and modulates the clinical outcome of stroke patients. However, the mechanism that dictates this process is unknown. Bone marrow-derived endothelial progenitor cells (EPCs) promote endothelial repair...
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