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Article

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.

PloS one - 1 Jan 2012

Raphel Linda, Talasila Amarnath, Cheung Christine, Sinha Sanjay

Abstract excerpt

BACKGROUND: Myocardin is thought to have a key role in smooth muscle cell (SMC) development by acting on CArG-dependent genes. However, it is unclear whether myocardin-induced SMC maturation and increases in agonist-induced calcium signalling are also associated with increases in the expression of non-CArG-dependent SMC-specific genes. Moreover, it is unknown whether myocardin promotes SMC development from human...

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Identifiers

PMID: 22937150
DOI: 10.1371/journal.pone.0044052
PMCID: PMC3429416

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