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Article

Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3.

Journal of neuropathology and experimental neurology - 1 Jan 2005

Zainelli Gina M, Dudek Nichole L, Ross Christopher A, Kim Soo-Youl, Muma Nancy A

Abstract excerpt

The most prominent neuropathologic hallmarks of Huntington disease (HD) are cortical and striatal perinuclear cytoplasmic aggregates and intranuclear inclusions of mutant huntingtin. Our laboratory previously demonstrated that huntingtin protein colocalizes with transglutaminase 2 and its product, the epsilon-(gamma-glutamyl)lysine bond in intranuclear inclusions in HD frontal cortex. We also found that...

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PMID: 15715085
DOI: 10.1093/jnen/64.1.58

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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