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Article

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.

12 Sept 1995

Abstract excerpt

The Huntington disease (HD) phenotype is associated with expansion of a trinucleotide repeat in the IT15 gene, which is predicted to encode a 348-kDa protein named huntington. We used polyclonal and monoclonal anti-fusion protein antibodies to identify native huntingtin in rat, monkey, and human. Western blots revealed a protein with the expected molecular weight which is present in the soluble fraction of rat...

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PMID: 7568002
DOI: 10.1073/pnas.92.19.8710

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies.PMID 7568002Read ↗

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Widespread expression of Huntington's disease gene (IT15) protein productSemantic proximity Read ↗

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Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionationSemantic proximity Read ↗

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