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Article

Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer.

International journal of cancer - 15 Dec 2010

Lacko Martin, Roelofs Hennie M J, Te Morsche Rene H M, Voogd Adri C, Ophuis Michel B Oude, Peters Wilbert H M, Manni Johannes J

Abstract excerpt

UDP-glucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degradation, but recent findings have shown that bilirubin is a potent antioxidant, which may play a protective role against cancer....

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Identifiers

PMID: 21351260
DOI: 10.1002/ijc.25296

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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