Article
CYP1A1 and GSTP1 polymorphisms in an oral cancer case-control study.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Dec 2006
Leichsenring A, Losi-Guembarovski R, Maciel M E, Losi-Guembarovski A, Oliveira B W, Ramos G, Cavalcanti T C S, Bicalho M G, Cavalli I J, Cólus I M S, Ribeiro E M S F
Abstract excerpt
CYP1A1 and GSTP1 polymorphisms have been associated with a higher risk to develop several cancers, including oral squamous cell carcinoma (OSCC), which is closely related to tobacco and alcohol consumption. Both genes code for enzymes that have an important role in activating or detoxifying carcinogenic elements found in tobacco and other compounds, and polymorphic variants of these genes may result in...
Topics
- Alleles
- Case-Control Studies
- Cytochrome P-450 CYP1A1
- Female
- Gene Frequency
- Genetic Markers
- Genetic Predisposition to Disease
- Glutathione S-Transferase pi
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
- Neoplasms, Squamous Cell