Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.

Head & neck - 1 Jun 2013

Lacko Martin, Voogd Adri C, Roelofs Hennie M J, te Morsche Rene H M, Oude Ophuis Michel B, Peters Wilbert H M, Manni Johannes J

Abstract excerpt

BACKGROUND: Combinations of genetic polymorphisms in biotransformation enzymes might modify the individual risk for head and neck cancer. METHODS: Blood from 432 patients with head and neck cancer and 437 controls was investigated for genetic polymorphisms in 9 different phase I and II biotransformation enzymes. Analysis of the risk-modifying effect was performed according to predicted enzyme activities, based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Cyclooxygenase 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epoxide Hydrolases

Share to Glucuronosyltransferase

Share to Head and Neck Neoplasms

Share to Logistic Models

Share to Smoking

Share to Young Adult

Source

Identifiers

PMID: 22715028
DOI: 10.1002/hed.23054

Genes

EPHX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.PMID 22715028Read ↗

Association between GSTP1, GSTM1 and GSTT1 polymorphisms involved in xenobiotic metabolism and head and neck cancer development.Semantic proximity Read ↗

Synergistic polymorphic interactions of phase II metabolizing genes and their association toward lung cancer susceptibility in North Indians.Semantic proximity Read ↗

CYP1A1, CYP2E1, GSTM1, GSTT1, EPHX1 exons 3 and 4, and NAT2 polymorphisms, smoking, consumption of alcohol and fruit and vegetables and risk of head and neck cancer.Semantic proximity Read ↗

Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer.Semantic proximity Read ↗

Functional CYP1A1 genetic variants, alone and in combination with smoking, contribute to development of head and neck cancers.Semantic proximity Read ↗

Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Genetic variations and head and neck cancer risks.Semantic proximity Read ↗

Association of CYP1A1 and CYP2D6 gene polymorphisms with head and neck cancer in Tunisian patients.Semantic proximity Read ↗

High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers.Semantic proximity Read ↗

Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.Semantic proximity Read ↗

Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis.Semantic proximity Read ↗

The PstI/RsaI and DraI polymorphisms of CYP2E1 and head and neck cancer risk: a meta-analysis based on 21 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.