Article
High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
International journal of oncology - 1 Jun 2012
Dura Polat, Salomon Jody, Te Morsche Rene H M, Roelofs Hennie M J, Kristinsson Jon O, Wobbes Theo, Witteman Ben J M, Tan Adriaan C I T L, Drenth Joost P H, Peters Wilbert H M
Abstract excerpt
Esophageal cancer (EC) has a globally increasing incidence with poor curative treatment options and survival rates. Environmental and dietary factors have crucial roles in esophageal carcinogenesis. Polymorphisms in the UGT genes, a superfamily of enzymes essential for the detoxification of carcinogens, may alter enzyme activity and subsequently may play a role in EC etiology. Rather than solely establishing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.