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Article

Independent roles of Fgfr2 and Frs2α in ureteric epithelium

25 Feb 2011

Abstract excerpt

Mice with conditional deletion of fibroblast growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2(UB-/-)) develop severe ureteric branching defects; however, ureteric deletion of fibroblast growth factor receptor substrate 2α (Frs2α), a key docking protein that transmits fibroblast growth factor receptor intracellular signaling (Frs2α(UB-/-)) leads to mild ureteric defects. Mice with...

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PMID: 21350013
DOI: 10.1242/dev.062158

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