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Article

Fgfr2 is integral for bladder mesenchyme patterning and function.

American journal of physiology. Renal physiology - 1 Apr 2017

Ikeda Y, Zabbarova I, Schaefer C M, Bushnell D, De Groat W C, Kanai A, Bates C M

Abstract excerpt

While urothelial signals, including sonic hedgehog (Shh), drive bladder mesenchyme differentiation, it is unclear which pathways within the mesenchyme are critical for its development. Studies have shown that fibroblast growth factor receptor 2 (Fgfr2) is necessary for kidney and ureter mesenchymal development. Our objective was to determine the role of Fgfr2 in bladder mesenchyme. We used Tbx18cre mice to delete...

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Share to Gestational Age
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle Contraction

Share to Muscle, Smooth

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Share to Receptor, Fibroblast Growth Factor, Type 2

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Source

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Identifiers

PMID: 28052872
DOI: 10.1152/ajprenal.00463.2016
PMCID: PMC5407073

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