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Article

A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype.

Circulation. Cardiovascular genetics - 1 Jun 2009

Hu Dan, Barajas-Martinez Hector, Burashnikov Elena, Springer Michael, Wu Yuesheng, Varro Andras, Pfeiffer Ryan, Koopmann Tamara T, Cordeiro Jonathan M, Guerchicoff Alejandra, Pollevick Guido D, Antzelevitch Charles

Abstract excerpt

BACKGROUND: Brugada syndrome, characterized by ST-segment elevation in the right precordial ECG leads and the development of life-threatening ventricular arrhythmias, has been associated with mutations in 6 different genes. We identify and characterize a mutation in a new gene. METHODS AND RESULTS: A 64-year-old white male displayed a type 1 ST-segment elevation in V1 and V2 during procainamide challenge....

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Identifiers

PMID: 20031595
DOI: 10.1161/CIRCGENETICS.108.829192
PMCID: PMC2801870

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Source receipt: pubmed, retrieved 7 Sept 2026.

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