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Article

A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Na(v)1.5 and K(v)4.3 channel currents.

Heart rhythm - 1 May 2012

Hu Dan, Barajas-Martínez Hector, Medeiros-Domingo Argelia, Crotti Lia, Veltmann Christian, Schimpf Rainer, Urrutia Janire, Alday Aintzane, Casis Oscar, Pfeiffer Ryan, Burashnikov Elena, Caceres Gabriel, Tester David J, Wolpert Christian, Borggrefe Martin, Schwartz Peter, Ackerman Michael J, Antzelevitch Charles

Abstract excerpt

BACKGROUND: Cardiac sodium channel β-subunit mutations have been associated with several inherited cardiac arrhythmia syndromes. OBJECTIVE: To identify and characterize variations in SCN1Bb associated with Brugada syndrome (BrS) and sudden infant death syndrome (SIDS). METHODS: All known exons and intron borders of the BrS-susceptibility genes were amplified and sequenced in both directions. Wild type (WT) and...

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Source

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Identifiers

PMID: 22155597
DOI: 10.1016/j.hrthm.2011.12.006
PMCID: PMC3334446

Genes

KCND3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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