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Article

Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death.

Human mutation - 1 Jun 2012

Giudicessi John R, Ye Dan, Kritzberger Chad J, Nesterenko Vladislav V, Tester David J, Antzelevitch Charles, Ackerman Michael J

Abstract excerpt

Heritable arrhythmia syndromes, including Brugada syndrome (BrS) and idiopathic ventricular fibrillation (IVF), may serve as the pathogenic basis for autopsy-negative sudden unexplained death (SUD) and sudden infant death syndrome (SIDS). Emerging evidence has linked perturbations in the transient outward current (I(to) ) conducted by the KCND3-encoded Kv4.3 pore-forming α-subunit to BrS or IVF. However, the...

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Source

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Identifiers

PMID: 22457051
DOI: 10.1002/humu.22058
PMCID: PMC3518919

Genes

KCND3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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