Article
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
Clinical and translational science - 1 Feb 2011
Parsa Afshin, Chang Yen-Pei C, Kelly Reagan J, Corretti Mary C, Ryan Kathleen A, Robinson Shawn W, Gottlieb Stephen S, Kardia Sharon L R, Shuldiner Alan R, Liggett Stephen B
Abstract excerpt
A three-stage approach was undertaken using genome-wide, case-control, and case-only association studies to identify genetic variants associated with heart failure mortality. In an Amish founder population (n = 851), cardiac hypertrophy, a trait integral to the adaptive response to failure, was f...
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