Article
Phylogeography of var gene repertoires reveals fine-scale geospatial clustering of Plasmodium falciparum populations in a highly endemic area.
Molecular ecology - 1 Jan 2015
Tessema Sofonias K, Monk Stephanie L, Schultz Mark B, Tavul Livingstone, Reeder John C, Siba Peter M, Mueller Ivo, Barry Alyssa E
Abstract excerpt
Plasmodium falciparum malaria is a major global health problem that is being targeted for progressive elimination. Knowledge of local disease transmission patterns in endemic countries is critical to these elimination efforts. To investigate fine-scale patterns of malaria transmission, we have compared repertoires of rapidly evolving var genes in a highly endemic area. A total of 3680 high-quality DBLα-sequences...
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