High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes.

doi:10.1111/j.1349-7006.1992.tb01992.x

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Article

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes.

Japanese journal of cancer research : Gann - 1 Aug 1992

Hayashi S, Watanabe J, Kawajiri K

Abstract excerpt

Lung cancer is closely associated with cigarette smoking. Aromatic hydrocarbons in smoke, including benzo[a]pyrene, first require metabolic activation by Phase I enzymes, cytochrome P450, to their ultimate forms, and these activated forms are then subjected to detoxification by Phase II enzymes, especially glutathione S-transferases. Thus, genetically determined susceptibility to lung cancer may depend on the...

Topics

Adenocarcinoma
Amino Acid Sequence
Base Sequence
Carcinoma, Squamous Cell
Cytochrome P-450 Enzyme System
DNA
DNA, Neoplasm
Disease Susceptibility
Genotype
Glutathione Transferase
Isoenzymes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lung Neoplasms

Molecular Sequence Data

Neoplasms

Oligonucleotide Probes

Polymerase Chain Reaction

Polymorphism, Genetic

Reference Values

Source

Open in PubMed Open full text

Identifiers

PMID: 1399823
DOI: 10.1111/j.1349-7006.1992.tb01992.x
PMCID: PMC5918950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1399823-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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