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Article

High susceptibility to lung cancer analyzed in terms of combined genotypes of P450IA1 and Mu-class glutathione S-transferase genes.

Japanese journal of cancer research : Gann - 1 Aug 1992

Hayashi S, Watanabe J, Kawajiri K

Abstract excerpt

Lung cancer is closely associated with cigarette smoking. Aromatic hydrocarbons in smoke, including benzo[a]pyrene, first require metabolic activation by Phase I enzymes, cytochrome P450, to their ultimate forms, and these activated forms are then subjected to detoxification by Phase II enzymes, especially glutathione S-transferases. Thus, genetically determined susceptibility to lung cancer may depend on the...

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Identifiers

PMID: 1399823
DOI: 10.1111/j.1349-7006.1992.tb01992.x
PMCID: PMC5918950

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