Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microinjection of baclofen and CGP7930 into the ventral tegmental area suppresses alcohol self-administration in alcohol-preferring rats.

Neuropharmacology - 1 Jul 2018

Maccioni Paola, Lorrai Irene, Contini Andrea, Leite-Morris Kimberly, Colombo Giancarlo

Abstract excerpt

Systemic administration of the orthosteric agonist, baclofen, and several positive allosteric modulators (PAMs) of the GABAB receptor has repeatedly been reported to decrease operant oral alcohol self-administration in rats. The aim of the present study was to evaluate the contribution of the mesolimbic dopamine system to the reducing effect of baclofen and GABAB PAMs on the reinforcing properties of alcohol. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Central Nervous System Depressants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethanol

Share to Microinjections

Share to Motor Activity

Share to Phenols

Share to Self Administration

Share to Ventral Tegmental Area

Source

Identifiers

PMID: 29050951
DOI: 10.1016/j.neuropharm.2017.10.012

Genes

PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microinjection of baclofen and CGP7930 into the ventral tegmental area suppresses alcohol self-administration in alcohol-preferring rats.PMID 29050951Read ↗

Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.Semantic proximity Read ↗

Current Pharmacotherapies for Alcohol Use Disorder in Italy: From Neurobiological Targets to Clinical PracticeSemantic proximity Read ↗

Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats.Semantic proximity Read ↗

K <sub>v</sub> 7 Channel Opener Retigabine Reduces Self-Administration of Cocaine but Not Sucrose in RatsSemantic proximity Read ↗

Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.Semantic proximity Read ↗

Behavioral neurobiology of alcohol addiction: recent advances and challenges.Semantic proximity Read ↗

GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry.Semantic proximity Read ↗

Are sweetened drinks a gateway to alcohol, opiate and stimulant addiction? Summary of evidence and therapeutic strategies.Semantic proximity Read ↗

Blockade of mesolimbic dopamine transmission dramatically increases sensitivity to the rewarding effects of nicotine in the ventral tegmental area.Semantic proximity Read ↗

Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment.Semantic proximity Read ↗

Suppression of ethanol responding by centrally administered CTOP and naltrindole in AA and Wistar rats.Semantic proximity Read ↗

Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.