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Article

In vivo kinetics of murine hemopoietic stem cells

15 Nov 2000

Abstract excerpt

We used stochastic modeling and computer simulation to study the replication, apoptosis, and differentiation of murine hemopoietic stem cells (HSCs) in vivo. This approach allows description of the behavior of an unobserved population (ie, HSCs) on the basis of the behavior of observed progeny cells (ie, granulocytes and lymphocytes). The results of previous limiting-dilution, competitive-repopulation studies in...

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PMID: 11071634
DOI: 10.1182/blood.v96.10.3399

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