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Article

Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.

Cancer research - 1 Apr 2011

Rose Amy E, Poliseno Laura, Wang Jinhua, Clark Michael, Pearlman Alexander, Wang Guimin, Vega Y Saenz de Miera Eleazar C, Medicherla Ratna, Christos Paul J, Shapiro Richard, Pavlick Anna, Darvishian Farbod, Zavadil Jiri, Polsky David, Hernando Eva, Ostrer Harry, Osman Iman

Abstract excerpt

Superficial spreading melanoma (SSM) and nodular melanoma (NM) are believed to represent sequential phases of linear progression from radial to vertical growth. Several lines of clinical, pathologic, and epidemiologic evidence suggest, however, that SSM and NM might be the result of independent pathways of tumor development. We utilized an integrative genomic approach that combines single nucleotide polymorphism...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21343389
DOI: 10.1158/0008-5472.CAN-10-2958
PMCID: PMC3070783

Genes

MTAP
DIS3
GALNT7
USO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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