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Article

Evolutionary Routes in Metastatic Uveal Melanomas Depend on MBD4 Alterations

21 Jun 2019

Abstract excerpt

Abstract Purpose: Uveal melanomas (UM) are genetically simple tumors carrying few copy number alterations (CNA) and a low mutation burden, except in rare MBD4-deficient, hypermutated cases. The genomics of uveal melanoma metastatic progression has not been described. We assessed the genetic heterogeneity of primary and metastatic MBD4-proficient and -deficient uveal melanomas. Experimental Design: We...

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PMID: 31227496
DOI: 10.1158/1078-0432.ccr-19-1215

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