Article
Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma.
PloS one - 8 Apr 2011
Valsesia Armand, Rimoldi Donata, Martinet Danielle, Ibberson Mark, Benaglio Paola, Quadroni Manfredo, Waridel Patrice, Gaillard Muriel, Pidoux Mireille, Rapin Blandine, Rivolta Carlo, Xenarios Ioannis, Simpson Andrew J G, Antonarakis Stylianos E, Beckmann Jacques S, Jongeneel C Victor, Iseli Christian, Stevenson Brian J
Abstract excerpt
Cancer genomes frequently contain somatic copy number alterations (SCNA) that can significantly perturb the expression level of affected genes and thus disrupt pathways controlling normal growth. In melanoma, many studies have focussed on the copy number and gene expression levels of the BRAF, PTEN and MITF genes, but little has been done to identify new genes using these parameters at the genome-wide scale....
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