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Article

Modulation of the functional binding sites for TGF-beta on the type II receptor leads to suppression of TGF-beta signaling.

Oncogene - 17 May 2007

Shimanuki T, Hara T, Furuya T, Imamura T, Miyazono K

Abstract excerpt

Transforming growth factor-beta (TGF-beta) binds to two different types of serine/threonine kinase receptors termed type II (TbetaR-II) and type I (TbetaR-I). TGF-beta is unable to bind to TbetaR-I in the absence of TbetaR-II, and initiates receptor assembly by binding with high affinity to TbetaR-II. Previous structural analysis of the TGF-beta3-TbetaR-II complex has suggested that two charged amino acid...

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PMID: 17146441
DOI: 10.1038/sj.onc.1210123

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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