Article
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.
Cell - 24 Jan 2003
Šošić Drazen, Richardson James A, Yu Kai, Ornitz David M, Olson Eric N
Abstract excerpt
During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm formation. We show here that the mammalian twist proteins, twist-1 and -2, are induced by a cytokine signaling pathway that requires the dorsal-related protein RelA, a member of the NF-kappaB family of transcription factors. Twist-1 and -2 repress cytokine gene...
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