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Toward Systems Metabolic Engineering of Streptomycetes for Secondary Metabolites Production

27 Oct 2017

Abstract excerpt

Streptomycetes are known for their inherent ability to produce pharmaceutically relevant secondary metabolites. Discovery of medically useful, yet novel compounds has become a great challenge due to frequent rediscovery of known compounds and a consequent decline in the number of relevant clinical trials in the last decades. A paradigm shift took place when the first whole genome sequences of streptomycetes...

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PMID: 29076639
DOI: 10.1002/biot.201700465

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