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A guide to genome mining and genetic manipulation of biosynthetic gene clusters in Streptomyces

29 Apr 2025

Abstract excerpt

Streptomyces are a crucial source of bioactive secondary metabolites with significant clinical applications. Recent studies of bacterial and metagenome-assembled genomes have revealed that Streptomyces harbors a substantial number of uncharacterized silent secondary metabolite biosynthetic gene clusters (BGCs). These BGCs represent a vast diversity of biosynthetic pathways for natural product synthesis,...

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PMID: 40313146
DOI: 10.71150/jm.2409026

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