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Article

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.

Development (Cambridge, England) - 1 Oct 2008

Caubit Xavier, Lye Claire M, Martin Elise, Coré Nathalie, Long David A, Vola Christine, Jenkins Dagan, Garratt Alistair N, Skaer Helen, Woolf Adrian S, Fasano Laurent

Abstract excerpt

Ureteric contractions propel foetal urine from the kidney to the urinary bladder. Here, we show that mouse ureteric smooth muscle cell (SMC) precursors express the transcription factor teashirt 3 (TSHZ3), and that Tshz3-null mutant mice have congenital hydronephrosis without anatomical obstruction. Ex vivo, the spontaneous contractions that occurred in proximal segments of wild-type embryonic ureter explants were...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18776146
DOI: 10.1242/dev.022442

Genes

BMP4
SHH
TSHZ3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4.PMID 18776146Read ↗

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ZEB2 signaling is essential for ureteral smooth muscle cell differentiation and maintenanceSemantic proximity Read ↗

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PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype.Semantic proximity Read ↗

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