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Article

Heterotaxin: a TGF-β signaling inhibitor identified in a multi-phenotype profiling screen in Xenopus embryos.

Chemistry & biology - 25 Feb 2011

Dush Michael K, McIver Andrew L, Parr Meredith A, Young Douglas D, Fisher Julie, Newman Donna R, Sannes Philip L, Hauck Marlene L, Deiters Alexander, Nascone-Yoder Nanette

Abstract excerpt

Disruptions of anatomical left-right asymmetry result in life-threatening heterotaxic birth defects in vital organs. We performed a small molecule screen for left-right asymmetry phenotypes in Xenopus embryos and discovered a pyridine analog, heterotaxin, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left-right asymmetric gene expression. Heterotaxin analogs also...

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Share to Drug Evaluation, Preclinical
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Physiologic

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Share to Transforming Growth Factor beta

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Source

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Identifiers

PMID: 21338922
DOI: 10.1016/j.chembiol.2010.12.008
PMCID: PMC3050558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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