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A method for human teratogen detection by geometrically confined cell differentiation and migration

12 May 2015

Abstract excerpt

Unintended exposure to teratogenic compounds can lead to various birth defects; however current animal-based testing is limited by time, cost and high inter-species variability. Here, we developed a human-relevant in vitro model, which recapitulated two cellular events characteristic of embryogenesis, to identify potentially teratogenic compounds. We spatially directed mesoendoderm differentiation,...

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PMID: 25966467
DOI: 10.1038/srep10038

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