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Article

SERPINA1 11478G→A variant, serum α1-antitrypsin, exacerbation frequency and FEV1 decline in COPD.

Thorax - 1 May 2011

Quint Jennifer K, Donaldson Gavin C, Kumari Meena, Talmud Philippa J, Hurst John R

Abstract excerpt

BACKGROUND: The α(1)-antitrypsin 11478G→A polymorphism may be associated with attenuated acute α(1)-antitrypsin responses. It was hypothesised that patients with chronic obstructive pulmonary disease (COPD) and this mutation have accelerated lung function decline. OBJECTIVE: To assess whether the 11478G→A polymorphism is associated with attenuated α(1)-antitrypsin responses at COPD exacerbation, and therefore...

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Source

Identifiers

PMID: 21335450
DOI: 10.1136/thx.2010.152975

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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