Article
Should the number of acute exacerbations in the previous year be used to guide treatments in COPD?
The European respiratory journal - 1 Feb 2021
Sadatsafavi Mohsen, McCormack James, Petkau John, Lynd Larry D, Lee Tae Yoon, Sin Don D
Abstract excerpt
BACKGROUND: In contemporary management of chronic obstructive pulmonary disease (COPD), the frequent exacerbator phenotype, based on a 12-month history of acute exacerbation of COPD (AECOPD), is a major determinant of therapeutic recommendations. However, there is considerable debate as to the stability of this phenotype over time. METHODS: We used fundamental principles in time-to-event analysis to demonstrate...
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