Article
Functional effects of mutations in cytochrome c oxidase related to prostate cancer.
Biochimica et biophysica acta - 1 Oct 2011
Namslauer Ida, Dietz Marina S, Brzezinski Peter
Abstract excerpt
A number of missense mutations in subunit I of cytochrome c oxidase (CytcO) have previously been linked to prostate cancer (Petros et al., 2005). To investigate the effects of these mutations at the molecular level, in the present study we prepared four different structural variants of the bacterial Rhodobacter sphaeroides CytcO (cytochrome aa(3)), each carrying one amino-acid residue replacement corresponding to...
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