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Article

Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models.

European journal of biochemistry - 1 Mar 2003

Bratton Melyssa, Mills Denize, Castleden C Kate, Hosler Jonathan, Meunier Brigitte

Abstract excerpt

Mitochondrial cytochrome c oxidase is a key protonmotive component of the respiratory chain. Mutations in the mitochondrially-encoded subunits of the complex have been reported in association with a range of diseases. In this work we used yeast and bacterial mutants to assess the effect of human mutations in subunit 1 (L196I) and subunit 3 (G78S, A200T, Delta F94-F98, F251L and W249Stop). While the stop mutation...

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PMID: 12631280
DOI: 10.1046/j.1432-1033.2003.03482.x

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