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Article

A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Namslauer Ida, Brzezinski Peter

Abstract excerpt

An increasing number of cancer types have been found to be linked to specific mutations in the mitochondrial DNA, which result in specific structural changes of the respiratory enzyme complexes. In this study, we have investigated the effect of 2 such mutations identified in colon cancer patients...

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Share to Biological Transport
Share to Colonic Neoplasms
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex IV

Share to Oxidation-Reduction

Share to Protein Structure, Quaternary

Share to Protons

Share to Rhodobacter sphaeroides

Source

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Identifiers

PMID: 19218458
DOI: 10.1073/pnas.0811450106
PMCID: PMC2651238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19218458-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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