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Article

Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides.

Biochimica et biophysica acta - 1 Oct 2009

Egawa Tsuyoshi, Lee Hyun Ju, Gennis Robert B, Yeh Syun-Ru, Rousseau Denis L

Abstract excerpt

The R481 residue in cytochrome c oxidase from Rhodobacter sphaeroides forms hydrogen bonds with the propionate groups of both heme a and heme a(3). It has been postulated that R481 is the proton loading site in the proton exit pathway essential for proton translocation. A recent functional study showed that the mutations of R481 to His, Leu and Gln cause the reduction of the activity to approximately 5-18% of the...

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Identifiers

PMID: 19463779
DOI: 10.1016/j.bbabio.2009.05.006
PMCID: PMC2874421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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