Article
p53 gene alterations and human papillomavirus type 16 infection in early stages of cervical carcinoma in Serbia.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000
Malisic E, Jankovic R, Majkic M, Dobricic J, Radulovic S
Abstract excerpt
PURPOSE: The incidence rate (age-standardized) of cervical carcinoma in Serbia is the highest in Europe. p53 is mainly inactivated at protein level in carcinomas associated with human papillomavirus (HPV) infection, such as cervical carcinomas. These tumors show low rate of p53 mutations. It is not clear if p53 mutations confer additional impact on disease prognosis. The role of polymorphic variant at codon 72 of...
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