Article
Frequent ras gene mutations in squamous cell cervical cancer.
Cancer letters - 16 Aug 1995
Wong Y F, Chung T K, Cheung T H, Lam S K, Xu Y G, Chang A M
Abstract excerpt
Eighty samples of cervical invasive squamous cell carcinoma were examined for ras gene mutations using polymerase chain reaction (PCR) followed by restriction enzyme digestion. We found 28 (35%) cervical cancers contained ras mutations at H-ras codon 12, 49 (61%) at K-ras codon 12, and 5 (6%) at K-ras codon 13. There were no significant differences in incidence of the ras gene mutations among different histologic...
Topics
- Alleles
- Base Sequence
- Carcinoma, Squamous Cell
- Cell Differentiation
- DNA Primers
- Female
- Genes, ras
- Humans
- Molecular Sequence Data
- Point Mutation
- Uterine Cervical Neoplasms