Article
Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.
Cancer - 1 Feb 1997
Cho J Y, Kim J H, Lee Y H, Chung K Y, Kim S K, Gong S J, You N C, Chung H C, Roh J K, Kim B S
Abstract excerpt
BACKGROUND: Mutations at codons 12, 13, and 61 of the three ras genes, H-ras, K-ras, and N-ras, convert these genes into active oncogenes. It appears that ras gene mutations can be found in a variety of tumor types. The purpose of this study was to evaluate the clinical significance of K-ras gene...
Topics
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
- DNA Probes
- Disease Progression
- Female
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Survival Analysis