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Article

Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays

1 Feb 2002

Abstract excerpt

The CCND1 gene, a key cell-cycle regulator, is often altered in breast cancer, but the mechanisms underlying CCND1 dysregulation and the clinical significance of CCND1 status are unclear. We used real-time quantitative PCR and RT-PCR assays based on fluorescent TaqMan methodology to quantify CCND1 gene amplification and expression in a large series of breast tumours. CCND1 overexpression was observed in 44...

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PMID: 11870541
DOI: 10.1038/sj.bjc.6600109

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