Article
Amino acid substitution in HCV core/NS5A region and genetic variation near IL28B gene affect treatment efficacy to interferon plus ribavirin combination therapy.
Intervirology - 1 Jan 2012
Akuta Norio, Suzuki Fumitaka, Hirakawa Miharu, Kawamura Yusuke, Sezaki Hitomi, Suzuki Yoshiyuki, Hosaka Tetsuya, Kobayashi Masahiro, Kobayashi Mariko, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Chayama Kazuaki, Nakamura Yusuke, Kumada Hiromitsu
Abstract excerpt
OBJECTIVE: To evaluate predictive factors of treatment efficacy to interferon (IFN)/ribavirin in patients infected with HCV genotype 1b (HCV-1b). METHODS: This study investigated pretreatment predictors, including viral- (aa substitutions in core aa 70/91 and NS5A-ISDR/IRRDR) and host-related factors (genetic variation near IL28B gene), to 48-week IFN/ribavirin in 490 Japanese adults infected with HCV-1b....
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