Role of interleukin-28B polymorphism as a predictor of sustained virological response in patients with chronic hepatitis C treated with triple therapy: a systematic review and meta-analysis.

doi:10.1007/s40261-013-0074-0

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Article

Role of interleukin-28B polymorphism as a predictor of sustained virological response in patients with chronic hepatitis C treated with triple therapy: a systematic review and meta-analysis.

Clinical drug investigation - 1 May 2013

Bota Simona, Sporea Ioan, Şirli Roxana, Neghină Adriana Maria, Popescu Alina, Străin Mihnea

Abstract excerpt

BACKGROUND AND OBJECTIVE: Chronic hepatitis C represents an important health problem. The aim of our meta-analysis was to establish the role of reference single nucleotide (rs) 12979860 allele of interleukin-28B (IL28B) CC versus CT+TT genotype (the most researched allele of IL28B) as a predictor of sustained virological response (SVR) in patients with chronic hepatitis C treated with triple therapy. METHODS: The...

Topics

Antiviral Agents
Drug Therapy, Combination
Gene Frequency
Genotype
Hepatitis C, Chronic
Humans
Interferon alpha-2
Interferon-alpha
Interferons
Interleukins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linear Models

Odds Ratio

Oligopeptides

Pharmacogenetics

Phenotype

Polyethylene Glycols

Polymorphism, Single Nucleotide

Proline

Source

Open in PubMed

Identifiers

PMID: 23532802
DOI: 10.1007/s40261-013-0074-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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