Article
Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing.
PloS one - 1 Jan 2012
Tso For Yue, Tully Damien C, Gonzalez Sandra, Quince Christopher, Ho On, Polacino Patricia, Ruprecht Ruth M, Hu Shiu-Lok, Wood Charles
Abstract excerpt
Understanding the evolution of the human immunodeficiency virus type 1 (HIV-1) envelope during disease progression can provide tremendous insights for vaccine development, and simian-human immunodeficiency virus (SHIV) infection of non-human primate provides an ideal platform for such studies. A newly developed clade C SHIV, SHIV-1157ipd3N4, which was able to infect rhesus macaques, closely resembled primary...
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