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Article

TGF‐β1 and WISP‐1/CCN‐4 can regulate each other's activity to cooperatively control osteoblast function

10 Apr 2008

Abstract excerpt

Wnt-induced secreted protein-1 (WISP-1), like other members of the CCN family, is expressed in skeletal tissues. Its mechanism of action remains unknown. Expression of WISP-1 was analyzed in human bone marrow stroma cells (hBMSC) by RT-PCR. We identified two major transcripts corresponding to those of full-length WISP-1, and of the splice variant WISP-1va which lacks a putative BMP/TGF-beta binding site. To...

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PMID: 18404666
DOI: 10.1002/jcb.21754

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