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Article

IL-17 Promotes the Phenotypic Transformation of Vascular Smooth Muscle Cells Through PI3K/AKT Signaling Pathway.

Microcirculation (New York, N.Y. : 1994) - 1 Jan 2026

Yao Song, Fu Tianfu, Tu Qingxian, Zhang Jie, Jiang Qianfeng, Xu Min, Wang Zhenglong, Jiao Yang, Tian Haixia

Abstract excerpt

BACKGROUND: Salt-sensitive hypertension (SSH) is associated with phenotypic changes in vascular smooth muscle cells (VSMCs). This study aimed to investigate the role of interleukin-17 (IL-17) in SSH and its impact on VSMC phenotype, focusing on the PI3K/AKT signaling pathway. METHODS: In vivo, an SSH rat model was established. Systolic blood pressure (SBP) was monitored, and mesenteric artery tissues were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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PMID: 41548145
DOI: 10.1111/micc.70050

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CCK

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