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Article

Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1.

FEBS letters - 23 Mar 2011

Sato Mizuho, Maruoka Masahiro, Yokota Naohiko, Kuwano Masayoshi, Matsui Akira, Inada Mika, Ogawa Takuya, Ishida-Kitagawa Norihiro, Takeya Tatsuo

Abstract excerpt

Abi-1 is an adaptor protein for Abelson kinase (c-Abl), and Abi-1 promotes the Abl-mediated phosphorylation of Mammalian Enabled (Mena) by binding both c-Abl and Mena. Here, we identified a new phosphorylation site (Y398) in the SH3 domain of Abi-1, and disruption of Y398, combined with the previously identified phosphorylation site Y213, significantly weakens the binding of Abi-1 to c-Abl. The SH3 domain of...

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PMID: 21320496
DOI: 10.1016/j.febslet.2011.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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