Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

doi:10.1101/gad.9.21.2569

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Article

Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity.

Genes & development - 1 Nov 1995

Dai Z, Pendergast A M

Abstract excerpt

A protein has been identified that interacts specifically with both the Src homologous 3 (SH3) domain and carboxy-terminal sequences of the c-Abl tyrosine kinase. The cDNA encoding the Abl interactor protein (Abi-2), was isolated from a human lymphocyte library using the yeast two-hybrid system with the Abl SH3 domain as bait. Abi-2 binds to c-Abl in vitro and in vivo. Abi-2 is a novel protein that contains an...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Binding Sites
Cell Transformation, Neoplastic
Cloning, Molecular
Homeodomain Proteins
Humans
Lymphocytes
Molecular Sequence Data
Mutation
Proline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein-Tyrosine Kinases

Proto-Oncogene Proteins c-abl

RNA

Sequence Homology, Amino Acid

Substrate Specificity

Tissue Distribution

src Homology Domains

Source

Open in PubMed

Identifiers

PMID: 7590236
DOI: 10.1101/gad.9.21.2569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7590236-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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