Article
Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.
FEBS letters - 4 Aug 2010
Dubielecka Patrycja M, Machida Kazuya, Xiong Xiaoling, Hossain Sajjad, Ogiue-Ikeda Mari, Carrera Ana C, Mayer Bruce J, Kotula Leszek
Abstract excerpt
Macropinocytosis is regulated by Abl kinase via an unknown mechanism. We previously demonstrated that Abl kinase activity is, itself, regulated by Abi1 subsequent to Abl kinase phosphorylation of Abi1 tyrosine 213 (pY213) [1]. Here we show that blocking phosphorylation of Y213 abrogated the ability of Abl to regulate macropinocytosis, implicating Abi1 pY213 as a key regulator of macropinocytosis. Results from...
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