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Aromatase (CYP19) promoter gene polymorphism and risk of nonviral hepatitis-related hepatocellular carcinoma.

Cancer - 1 Aug 2011

Koh Woon-Puay, Yuan Jian-Min, Wang Renwei, Govindarajan Sugantha, Oppenheimer Rowena, Zhang Zhen Quan, Yu Mimi C, Ingles Sue Ann

Abstract excerpt

BACKGROUND: Experimental studies suggest that sex hormones may induce or promote the development of hepatocellular carcinoma (HCC). Androgens are converted to estrogens by the CYP19 gene product, aromatase. Hepatic aromatase level and activity have been shown to be markedly elevated in HCC. Aromatase expression in liver tumors is driven by a promoter upstream of CYP19 exon I.6. METHODS: First, the authors...

Topics

Aged
Aromatase
Base Sequence
Carcinoma, Hepatocellular
Case-Control Studies
DNA Primers
Female
Genetic Predisposition to Disease
Hepatitis, Viral, Human
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21319151
DOI: 10.1002/cncr.25939
PMCID: PMC3138892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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