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Article

Sex steroid axes in determining male predominance in hepatocellular carcinoma

20 Dec 2022

Abstract excerpt

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms for male propensity in HCC incidence, prognosis and treatment responses are complicated and remain inconclusive. Sex-biased molecular signatures in carcinogenesis, viral infections and immune responses have been studied predominantly within the context of sex hormones effects. This review integrates current knowledge...

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PMID: 36563929
DOI: 10.1016/j.canlet.2022.216037

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