Article
Polymorphisms of estrogen-metabolizing genes and risk of hepatocellular carcinoma in Taiwan females.
Cancer letters - 30 Aug 2004
Yin Pen-Hui, Lee Hsin-Chen, Chau Gar-Yang, Liu Tsung-Yun, Liu Hsiu-Chih, Lui Wing-Yiu, Chi Chin-Wen
Abstract excerpt
Estrogen has been related to the development of hepatocellular carcinoma (HCC). In this molecular epidemiological study, we used logistic regression to compare the genotype frequencies of estrogen-metabolizing genes that are involved in estrogen biogenesis (CYP17), hydroxylation (CYP1A1) and inactivation of the reactive metabolites (catechol-O-methyltransferase, COMT) in HCC patients and control subjects, and...
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